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KMID : 0984720030350040211
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Infection and Chemotherapy
2003 Volume.35 No. 4 p.211 ~ p.214
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In Vitro Antimicrobial Activity of Cefditoren pivoxil, an Oral Cephalosporin, against Major Clinical Isolates
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Lee Jong-Youn
Lee Jae- Kyu
Kim Eui-Chong
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Abstract
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Background: Cefditoren is an oral cephalosporin with excellent activity against Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis, which are the predominant bacterial causes of community-acquired respiratory tract infections. The current study sttempted to determine the antibacterial activity of cefditoren against the major clinical isolates.
Methods: According to the NCCLS recommendations, antibacterial activities of cefditoren were measured against total 504 major clinical isolates. MICs were determined by the agar dilution method, a series of doubling dilutions from 128 to 0.03 ㎍/mL, on E. coli, K. pneumoniae, E. cloacae, C. freundii, S. marcescens, P. mirabilis, and Staphylococcus spp. In case of H. influenzae, S. pneumoniae, and M. catarrhalis, broth microdilution method, a series of doubling dilutions from 16 to 0.015 ㎍/mL, was performed.
Results: Cefditoren had variable activity against Enterobacteriaceae. MIC cumulative curves showed that cefditoren had low MIC distributions against E. coli and P mirabilis, and MIC(90) were 8 and 0.5 ㎍/mL, respectively Against K. pneumoniae, E. cloacae, C. freundii, and S. marcescens, cefditoren´s MIC(9O) values ranged from 32 to ＞128 ㎍/mL. For clinical isolates of methicillin-susceptible S. aureus and methicillin-susceptible S. epidermidis, cofditoren had MIC(9O) values of 1 ㎍/mL and 0.5 ㎍/mL, respectively. Cefditoren had MIC(9O) values of 1 ㎍/mL for penicillin-susceptible and penicillin-not susceptible strains of S. pneurmoniae. Cefditoren had MIC(9O) values of 0.03 ㎍/mL and 0.5 ㎍/mL against H. influenzae and M. catarrhalis, respectively.
Conclusion: Cefditoren had excellent activity against S. pneumoniae, H. influenzae, and M. catarrhalis. Cefditoren had variable activity against Enterobacteriaceae. The results of this study confirm the excellent activity of cefditoren against the major respiratory tract pathogens and suggest that cefditoren could be a good antibiotic for empiric oral treatment of community-acquired respiratory tract infections.
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KEYWORD
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cefditoren, antibiotic susceptibility, cephalosporin
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